The Venture Brothers is Johnny Quest on crack. Dr. Venture, his bodyguard Brock Samson (voiced by the incomparable Patrick Warburton), and Dr. Venture's two sons, Dean and Hank, who are the goofiest, strangest two boys you will ever see on television. The four of them run around having the most bizarre adventures.
After seeing a preview of the show on Cartoon Network way back in 2003, I knew I had to watch the show when it premiered. I've gotten to watch it a few times during its first season, and have always enjoyed its savage take on old adventure cartoons from the 60s and 70s. It's almost as good as Sealab 2021.
According to creator Jackson Publick's blog, Cartoon Network hasn't decided whether to order another season of the show or not. In an attempt to see if The Venture Brothers has staying power, CN is "trying" the show out in an earlier, more popular, timeslot in the Adult Swim programming. CN is running The Venture Brothers Sundays at 10:30 pm. So you've got some chances to catch it without having to stay up late.